Identification of well-differentiated gene expressions between Han Chinese and Japanese using genome-wide microarray data analysis
Identifieur interne : 000135 ( Main/Exploration ); précédent : 000134; suivant : 000136Identification of well-differentiated gene expressions between Han Chinese and Japanese using genome-wide microarray data analysis
Auteurs : Yuan Yuan [République populaire de Chine, Australie] ; Ling Yang [République populaire de Chine] ; Meng Shi [République populaire de Chine] ; Dongsheng Lu [République populaire de Chine] ; Haiyi Lou [République populaire de Chine] ; Yi-Ping Phoebe Chen [Australie] ; Li Jin [République populaire de Chine] ; Shuhua Xu [République populaire de Chine]Source :
- Journal of Medical Genetics [ 0022-2593 ] ; 2013-08.
Abstract
Background Investigating variations in gene expression, which can be quantitatively measured on a genome-wide scale, is essential to understand and interpret phenotypic differences among human populations. Several previous studies have examined and compared variations in gene expression between continental populations. However, differences in gene expression variation between closely related populations have not been studied yet. Method We performed a genome-wide analysis and systematically compared expression profiles of Han Chinese with those of the Japanese population. Results We identified 768 genes (4.4% of 17 354 expressed genes) which were expressed differentially between the two populations, with 165 showing highly differential expression and enriched in genes involved in the spliceosome pathway, mRNA processing, mRNA metabolic process, RNA processing, RNA splicing and mitochondrial transport. We further identified cis- and trans-variants that regulated these differential gene expressions, and found that cis-variants shared in the two populations were centred within a range of 200 kb around transcription start site. Our analysis indicated that genetic differences in the cis-associated genes between the two populations could explain 7–43% of the identified expression divergence. Conclusions In summary, despite considerable heterogeneity, gene expression profiles between Han Chinese and Japanese did show an overall difference, with well-differentiated expressions regulated by genetic variants which have been reported associated with hematological and biochemical traits in Japanese populations. Our results supported that gene expression is regulated by genetic variants and there is a genetic basis for the phenotypic differences between Han Chinese and Japanese populations.
Url:
DOI: 10.1136/jmedgenet-2012-101501
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 002588
- to stream Istex, to step Curation: 001C86
- to stream Istex, to step Checkpoint: 000025
- to stream Main, to step Merge: 000135
- to stream Main, to step Curation: 000135
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Identification of well-differentiated gene expressions between Han Chinese and Japanese using genome-wide microarray data analysis</title><author><name sortKey="Yuan, Yuan" sort="Yuan, Yuan" uniqKey="Yuan Y" first="Yuan" last="Yuan">Yuan Yuan</name></author><author><name sortKey="Yang, Ling" sort="Yang, Ling" uniqKey="Yang L" first="Ling" last="Yang">Ling Yang</name></author><author><name sortKey="Shi, Meng" sort="Shi, Meng" uniqKey="Shi M" first="Meng" last="Shi">Meng Shi</name></author><author><name sortKey="Lu, Dongsheng" sort="Lu, Dongsheng" uniqKey="Lu D" first="Dongsheng" last="Lu">Dongsheng Lu</name></author><author><name sortKey="Lou, Haiyi" sort="Lou, Haiyi" uniqKey="Lou H" first="Haiyi" last="Lou">Haiyi Lou</name></author><author><name sortKey="Chen, Yi Ping Phoebe" sort="Chen, Yi Ping Phoebe" uniqKey="Chen Y" first="Yi-Ping Phoebe" last="Chen">Yi-Ping Phoebe Chen</name></author><author><name sortKey="Jin, Li" sort="Jin, Li" uniqKey="Jin L" first="Li" last="Jin">Li Jin</name></author><author><name sortKey="Xu, Shuhua" sort="Xu, Shuhua" uniqKey="Xu S" first="Shuhua" last="Xu">Shuhua Xu</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:E109CFBB8E113AD2EC3338ADB331488BECE14D2E</idno><date when="2013" year="2013">2013</date><idno type="doi">10.1136/jmedgenet-2012-101501</idno><idno type="url">https://api.istex.fr/document/E109CFBB8E113AD2EC3338ADB331488BECE14D2E/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">002588</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002588</idno><idno type="wicri:Area/Istex/Curation">001C86</idno><idno type="wicri:Area/Istex/Checkpoint">000025</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000025</idno><idno type="wicri:doubleKey">0022-2593:2013:Yuan Y:identification:of:well</idno><idno type="wicri:Area/Main/Merge">000135</idno><idno type="wicri:Area/Main/Curation">000135</idno><idno type="wicri:Area/Main/Exploration">000135</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Identification of well-differentiated gene expressions between Han Chinese and Japanese using genome-wide microarray data analysis</title><author><name sortKey="Yuan, Yuan" sort="Yuan, Yuan" uniqKey="Yuan Y" first="Yuan" last="Yuan">Yuan Yuan</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Max Planck Independent Research Group on Population Genomics, Chinese Academy of Sciences and Max Planck Society (CAS-MPG) Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Computer Science and Computer Engineering, La Trobe University, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Ling" sort="Yang, Ling" uniqKey="Yang L" first="Ling" last="Yang">Ling Yang</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Max Planck Independent Research Group on Population Genomics, Chinese Academy of Sciences and Max Planck Society (CAS-MPG) Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Shi, Meng" sort="Shi, Meng" uniqKey="Shi M" first="Meng" last="Shi">Meng Shi</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Max Planck Independent Research Group on Population Genomics, Chinese Academy of Sciences and Max Planck Society (CAS-MPG) Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Lu, Dongsheng" sort="Lu, Dongsheng" uniqKey="Lu D" first="Dongsheng" last="Lu">Dongsheng Lu</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Max Planck Independent Research Group on Population Genomics, Chinese Academy of Sciences and Max Planck Society (CAS-MPG) Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Lou, Haiyi" sort="Lou, Haiyi" uniqKey="Lou H" first="Haiyi" last="Lou">Haiyi Lou</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Max Planck Independent Research Group on Population Genomics, Chinese Academy of Sciences and Max Planck Society (CAS-MPG) Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Yi Ping Phoebe" sort="Chen, Yi Ping Phoebe" uniqKey="Chen Y" first="Yi-Ping Phoebe" last="Chen">Yi-Ping Phoebe Chen</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Computer Science and Computer Engineering, La Trobe University, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Jin, Li" sort="Jin, Li" uniqKey="Jin L" first="Li" last="Jin">Li Jin</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Genetic Engineering and Ministry of Education (MOE) Key Laboratory of Contemporary Anthropology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Xu, Shuhua" sort="Xu, Shuhua" uniqKey="Xu S" first="Shuhua" last="Xu">Shuhua Xu</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Max Planck Independent Research Group on Population Genomics, Chinese Academy of Sciences and Max Planck Society (CAS-MPG) Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Medical Genetics</title><title level="j" type="abbrev">J Med Genet</title><idno type="ISSN">0022-2593</idno><idno type="eISSN">1468-6244</idno><imprint><publisher>BMJ Publishing Group Ltd</publisher><date type="published" when="2013-08">2013-08</date><biblScope unit="volume">50</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="534">534</biblScope></imprint><idno type="ISSN">0022-2593</idno></series><idno type="istex">E109CFBB8E113AD2EC3338ADB331488BECE14D2E</idno><idno type="DOI">10.1136/jmedgenet-2012-101501</idno><idno type="href">jmedgenet-50-534.pdf</idno><idno type="ArticleID">jmedgenet-2012-101501</idno><idno type="PMID">23735306</idno><idno type="local">jmedgenet;50/8/534</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-2593</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Background Investigating variations in gene expression, which can be quantitatively measured on a genome-wide scale, is essential to understand and interpret phenotypic differences among human populations. Several previous studies have examined and compared variations in gene expression between continental populations. However, differences in gene expression variation between closely related populations have not been studied yet. Method We performed a genome-wide analysis and systematically compared expression profiles of Han Chinese with those of the Japanese population. Results We identified 768 genes (4.4% of 17 354 expressed genes) which were expressed differentially between the two populations, with 165 showing highly differential expression and enriched in genes involved in the spliceosome pathway, mRNA processing, mRNA metabolic process, RNA processing, RNA splicing and mitochondrial transport. We further identified cis- and trans-variants that regulated these differential gene expressions, and found that cis-variants shared in the two populations were centred within a range of 200 kb around transcription start site. Our analysis indicated that genetic differences in the cis-associated genes between the two populations could explain 7–43% of the identified expression divergence. Conclusions In summary, despite considerable heterogeneity, gene expression profiles between Han Chinese and Japanese did show an overall difference, with well-differentiated expressions regulated by genetic variants which have been reported associated with hematological and biochemical traits in Japanese populations. Our results supported that gene expression is regulated by genetic variants and there is a genetic basis for the phenotypic differences between Han Chinese and Japanese populations.</div></front></TEI><affiliations><list><country><li>Australie</li><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Yuan, Yuan" sort="Yuan, Yuan" uniqKey="Yuan Y" first="Yuan" last="Yuan">Yuan Yuan</name></noRegion><name sortKey="Jin, Li" sort="Jin, Li" uniqKey="Jin L" first="Li" last="Jin">Li Jin</name><name sortKey="Lou, Haiyi" sort="Lou, Haiyi" uniqKey="Lou H" first="Haiyi" last="Lou">Haiyi Lou</name><name sortKey="Lu, Dongsheng" sort="Lu, Dongsheng" uniqKey="Lu D" first="Dongsheng" last="Lu">Dongsheng Lu</name><name sortKey="Shi, Meng" sort="Shi, Meng" uniqKey="Shi M" first="Meng" last="Shi">Meng Shi</name><name sortKey="Xu, Shuhua" sort="Xu, Shuhua" uniqKey="Xu S" first="Shuhua" last="Xu">Shuhua Xu</name><name sortKey="Yang, Ling" sort="Yang, Ling" uniqKey="Yang L" first="Ling" last="Yang">Ling Yang</name></country><country name="Australie"><noRegion><name sortKey="Yuan, Yuan" sort="Yuan, Yuan" uniqKey="Yuan Y" first="Yuan" last="Yuan">Yuan Yuan</name></noRegion><name sortKey="Chen, Yi Ping Phoebe" sort="Chen, Yi Ping Phoebe" uniqKey="Chen Y" first="Yi-Ping Phoebe" last="Chen">Yi-Ping Phoebe Chen</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Linguistique/explor/TamazightV2/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000135 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000135 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Linguistique
|area= TamazightV2
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:E109CFBB8E113AD2EC3338ADB331488BECE14D2E
|texte= Identification of well-differentiated gene expressions between Han Chinese and Japanese using genome-wide microarray data analysis
}}
| This area was generated with Dilib version V0.6.33. |  |